Response to parathyroid hormone

Across TCGA patient cohorts, RNA activity of the Response to parathyroid hormone pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HNMT, KANK2, and PRKG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to parathyroid hormone activity versus HNMT in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HNMT →	+0.538	+0.057	<.001	.001	3	9
BRCA	KANK2 →	+0.654	+0.072	<.001	<.001	3	9
UCEC	PRKG1 →	+0.561	+0.062	<.001	<.001	3	9
HNSC	EPB41L2_S87 →	+0.596	+0.071	<.001	<.001	3	8
LSCC	PHLDB1 →	+0.359	+0.088	<.001	<.001	3	8
LUAD	RRM2 →	-0.648	-0.066	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071107 vs HNMT — BRCA

Explore this scatter interactively →