Response to parathyroid hormone

Across TCGA cell cohorts, RNA activity of the Response to parathyroid hormone pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN5, SLC4A8, and ADAR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN5 grouped by Response to parathyroid hormone-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TSPAN5 →	-2.960	-1.950	<.001	<.001	3	5
CNS	SLC4A8 →	-1.330	-1.228	<.001	<.001	3	5
BONE	ADAR →	+1.171	+1.744	.004	<.001	3	4
BLOOD_Myeloma	FNBP1 →	-2.346	-1.295	<.001	.003	3	4
BREAST	PMF1 →	-0.831	-0.914	<.001	<.001	3	4
BONE	MRO →	+1.862	+1.236	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN5 by Response to parathyroid hormone activity — BONE

Explore this box plot interactively →