Response to parathyroid hormone

Across TCGA cell cohorts, RNA activity of the Response to parathyroid hormone pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOSB, FOS, and EGR1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to parathyroid hormone activity versus FOSB in OESOPHAGUS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FOSB →	+4.617	+0.377	<.001	<.001	3	17
OESOPHAGUS	FOS →	+4.685	+0.377	<.001	<.001	3	17
OESOPHAGUS	EGR1 →	+3.187	+0.228	<.001	<.001	3	15
OESOPHAGUS	JUNB →	+1.940	+0.228	<.001	<.001	3	14
OVARY	ZFP36 →	+1.908	+0.254	<.001	.001	3	10
OESOPHAGUS	DUSP1 →	+2.813	+0.216	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071107 vs FOSB — OESOPHAGUS

Explore this scatter interactively →