DNA conformation change

Across TCGA patient cohorts, RNA activity of the DNA conformation change pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO5, MCM3, and TTK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA conformation change activity versus FBXO5 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FBXO5 →	+0.858	+0.362	<.001	<.001	3	8
LSCC	MCM3 →	+0.748	+0.319	<.001	<.001	3	8
LSCC	TTK →	+1.291	+0.370	<.001	<.001	3	8
BRCA	NEK2 →	+1.157	+0.314	<.001	<.001	3	8
LSCC	HELLS →	+1.115	+0.398	<.001	<.001	3	8
LSCC	TMPO →	+0.847	+0.316	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071103 vs FBXO5 — LSCC

Explore this scatter interactively →