RNA 3' uridylation

pathway activity — cross-omics
GO:0071076Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the RNA 3' uridylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCAT19, MIR4324, and ADGRD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPCAT19 →-0.933-0.582<.001.00134
GBMMIR4324 →+0.704+0.318.001.00333
PDACADGRD1 →-0.478-0.343.007.00624
PDACKIF18A →+0.465+0.309.002.00233
BRCAKLHL3 →-0.607-0.357<.001.00333
LSCCLOXL1 →-0.731-0.543<.001.00333
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration