Poly(A)-dependent snoRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the Poly(A)-dependent snoRNA 3'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UHRF2, VCP, and DNAJA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly(A)-dependent snoRNA 3'-end processing activity versus UHRF2 in COAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UHRF2 →	+0.282	+0.025	.001	.003	3	7
GBM	VCP →	+0.261	+0.041	<.001	.001	3	6
LSCC	DNAJA1 →	+0.262	+0.059	<.001	<.001	3	6
GBM	DDOST →	-0.265	-0.039	<.001	<.001	3	6
UCEC	RPN1 →	-0.458	-0.085	.004	.002	3	5
OV	TENT4B →	+0.411	+0.051	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071051 vs UHRF2 — COAD

Explore this scatter interactively →