Poly(A)-dependent snoRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the Poly(A)-dependent snoRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMOC2, LAMA2, and GEMIN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly(A)-dependent snoRNA 3'-end processing activity versus SMOC2 in HNSC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMOC2 →	-0.984	-0.154	<.001	<.001	3	5
HNSC	LAMA2 →	-0.697	-0.108	.007	.006	3	4
GBM	GEMIN4 →	+0.398	+0.124	.002	.001	3	4
PDAC	CPE →	-0.723	-0.141	.002	.004	3	3
HNSC	DCN →	-0.855	-0.129	.003	.001	3	3
PDAC	EDA2R →	-0.430	-0.139	.007	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071051 vs SMOC2 — HNSC

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