Histone mRNA catabolic process

Across TCGA patient cohorts, RNA activity of the Histone mRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPA, KANK2, and DACT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histone mRNA catabolic process activity versus ASPA in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASPA →	-0.377	-0.122	.003	.003	3	5
BRCA	KANK2 →	-0.709	-0.203	.003	.001	3	5
BRCA	DACT3 →	-0.556	-0.207	.005	.001	3	5
LUAD	LAMA2 →	-0.866	-0.271	<.001	<.001	3	5
BRCA	CYBRD1 →	-1.360	-0.207	.002	.001	3	5
UCEC	GUCY1A2 →	-1.155	-0.380	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071044 vs ASPA — BRCA

Explore this scatter interactively →