Histone mRNA catabolic process

Across TCGA patient cohorts, RNA activity of the Histone mRNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EHD2_S438, TTC7B, and SVIL_S245, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histone mRNA catabolic process activity versus EHD2_S438 in UCEC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EHD2_S438 →	-1.067	-0.421	<.001	<.001	3	5
GBM	TTC7B →	-0.338	-0.181	<.001	.004	3	5
UCEC	SVIL_S245 →	-0.764	-0.327	.001	<.001	3	4
GBM	SYNPO_S580 →	-0.653	-0.216	<.001	.001	3	4
UCEC	SYNPO_S685 →	-0.552	-0.248	.003	.001	2	5
CCRCC	TNS2_S941 →	-0.576	-0.371	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071044 vs EHD2_S438 — UCEC

Explore this scatter interactively →