CUT catabolic process

Across TCGA patient cohorts, RNA activity of the CUT catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF19, IK, and PRPF4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CUT catabolic process activity versus PRPF19 in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PRPF19 →	+0.207	+0.026	<.001	.006	3	9
GBM	IK →	+0.345	+0.072	<.001	<.001	3	8
LSCC	PRPF4 →	+0.218	+0.050	.002	<.001	3	8
LSCC	SMU1 →	+0.217	+0.060	<.001	<.001	3	8
BRCA	UHRF2 →	+0.361	+0.048	<.001	<.001	3	8
LSCC	APTX →	+0.457	+0.066	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071034 vs PRPF19 — PDAC

Explore this scatter interactively →