CUT catabolic process

Across TCGA patient cohorts, RNA activity of the CUT catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMX1, MIS18BP1, and SASS6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CUT catabolic process activity versus TMX1 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMX1 →	+0.480	+0.149	.002	.007	3	4
BRCA	MIS18BP1 →	+0.434	+0.149	.006	.008	3	3
BRCA	SASS6 →	+0.562	+0.170	.001	.009	3	3
BRCA	RRM1 →	+0.358	+0.176	.009	.009	2	4
BRCA	G2E3 →	+0.359	+0.146	<.001	.001	3	3
OV	WBP1P2 →	-0.711	-0.120	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071034 vs TMX1 — BRCA

Explore this scatter interactively →