CUT catabolic process

Across TCGA cell cohorts, RNA activity of the CUT catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHML, FBXO15, and BTBD11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHML grouped by CUT catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHML →	+1.180	+0.227	.003	<.001	3	4
LUNG_SCLC	FBXO15 →	-1.282	-0.819	<.001	.008	3	3
LUNG_NSCLC_LUSC	BTBD11 →	-2.321	-0.271	<.001	<.001	3	3
BREAST	WFDC3 →	-0.970	-0.743	.008	.003	3	3
BREAST	KIF1A →	-2.476	-1.020	<.001	<.001	2	4
SOFT_TISSUE	ZNF449 →	-1.024	-1.226	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHML by CUT catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →