CUT catabolic process

Across TCGA cell cohorts, RNA activity of the CUT catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCL1, HNRNPA1, and EXOSC8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CUT catabolic process activity versus RCL1 in BONE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RCL1 →	+1.830	+2.000	<.001	<.001	3	6
BREAST	HNRNPA1 →	+0.580	+1.229	.005	.001	3	6
LUNG_NSCLC_LUAD	EXOSC8 →	+0.685	+0.763	<.001	.002	3	5
PANCREAS	STAM2 →	-0.951	-1.664	<.001	<.001	3	5
BREAST	KLHL23 →	+1.052	+1.051	<.001	<.001	3	5
BONE	CTSB →	-2.811	-1.133	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071034 vs RCL1 — BONE

Explore this scatter interactively →