Nuclear mRNA surveillance

Across TCGA patient cohorts, RNA activity of the Nuclear mRNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGER2, CAT, and CCDC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear mRNA surveillance activity versus PTGER2 in PDAC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PTGER2 →	-0.533	-0.163	.003	.008	3	4
LSCC	CAT →	-0.366	-0.102	<.001	.007	3	3
BRCA	CCDC18 →	+0.508	+0.136	<.001	.001	3	3
HNSC	MAGEH1 →	-0.661	-0.091	.005	.008	3	3
HNSC	MIR1200 →	-0.715	-0.090	.009	.002	3	3
PDAC	LRRC31 →	-0.889	-0.235	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071028 vs PTGER2 — PDAC

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