Nuclear mRNA surveillance

Across TCGA cell cohorts, RNA activity of the Nuclear mRNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A5, RBM33, and CPT1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC44A5 grouped by Nuclear mRNA surveillance-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC44A5 →	-2.976	-0.344	<.001	.001	2	5
PANCREAS	RBM33 →	-0.690	-0.299	<.001	<.001	3	4
BONE	CPT1C →	-3.954	-0.596	.003	.004	3	4
BLOOD_Leukemia	C1orf216 →	-0.724	-0.213	.005	.001	3	3
KIDNEY	KLHL41 →	-0.102	-0.286	.002	.003	3	3
SKIN	STOML2 →	+0.656	+0.292	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC44A5 by Nuclear mRNA surveillance activity — PANCREAS

Explore this box plot interactively →