Nuclear mRNA surveillance

Across TCGA cell cohorts, RNA activity of the Nuclear mRNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOC3L, C20orf96, and MRTO4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear mRNA surveillance activity versus NOC3L in LUNG_NSCLC_LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NOC3L →	+0.678	+1.147	.001	.006	2	7
LUNG_NSCLC_LUAD	C20orf96 →	+0.773	+0.835	.003	.009	3	6
LUNG_NSCLC_LUAD	MRTO4 →	+0.965	+1.266	<.001	.004	3	6
URINARY_TRACT	TRMT1 →	+0.791	+1.638	.005	.001	2	7
PANCREAS	GEMIN5 →	+1.555	+2.341	<.001	<.001	3	6
PANCREAS	NUDC →	+0.981	+1.823	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071028 vs NOC3L — LUNG_NSCLC_LUAD

Explore this scatter interactively →