RNA surveillance

Across TCGA patient cohorts, RNA activity of the RNA surveillance pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHD4, NELFB, and PSIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA surveillance activity versus CHD4 in COAD (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CHD4 →	+0.144	+0.033	.009	<.001	3	6
GBM	NELFB →	+0.274	+0.047	<.001	.001	2	7
GBM	PSIP1 →	+0.527	+0.049	<.001	<.001	3	6
UCEC	HCFC1 →	+0.150	+0.078	<.001	<.001	3	6
LUAD	MEN1 →	+0.207	+0.030	.001	.007	3	6
GBM	TOP2B →	+0.225	+0.036	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071025 vs CHD4 — COAD

Explore this scatter interactively →