RNA surveillance

Across TCGA patient cohorts, RNA activity of the RNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC2, CENPH, and COLEC12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA surveillance activity versus SDC2 in LUAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SDC2 →	-0.969	-0.164	<.001	<.001	3	4
GBM	CENPH →	+0.844	+0.187	<.001	<.001	3	4
GBM	COLEC12 →	-0.721	-0.115	.002	.001	3	4
GBM	KATNBL1P3 →	+0.365	+0.129	<.001	<.001	3	4
COAD	CP →	-0.691	-0.129	.001	<.001	3	4
UCEC	CPAMD8 →	-0.924	-0.246	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071025 vs SDC2 — LUAD

Explore this scatter interactively →