RNA surveillance

Across TCGA cell cohorts, RNA activity of the RNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD46, LAMP2, and RBSN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA surveillance activity versus CD46 in CNS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CD46 →	-0.543	-1.139	.005	.001	3	7
LIVER	LAMP2 →	-1.821	-1.761	.001	<.001	3	7
SKIN	RBSN →	+0.560	+1.152	.008	.009	3	7
PANCREAS	CHCHD4 →	+1.531	+1.694	<.001	<.001	3	7
BLOOD_Leukemia	BRD3 →	+0.673	+0.863	.008	.009	3	6
OVARY	RPUSD4 →	+0.732	+1.178	.009	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071025 vs CD46 — CNS

Explore this scatter interactively →