Oxidative demethylation

Across TCGA patient cohorts, RNA activity of the Oxidative demethylation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2C8, CYP3A7, and CYP3A5, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative demethylation activity versus CYP2C8 in DLBC (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CYP2C8 →	-1.110	-0.079	<.001	<.001	3	21
KIRC	CYP3A7 →	-0.516	-0.031	<.001	<.001	3	21
ESCA	CYP3A5 →	-1.278	-0.034	.005	.005	1	20
THYM	LGALS1 →	+1.144	+0.039	<.001	<.001	3	18
ESCA	NUTF2 →	+0.484	+0.046	<.001	<.001	2	18
THYM	FTO →	+0.911	+0.045	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070989 vs CYP2C8 — DLBC

Explore this scatter interactively →