Oxidative demethylation

Across TCGA patient cohorts, RNA activity of the Oxidative demethylation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, LYSMD3_S134, and MTM1_S18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative demethylation activity versus SORBS3 in COAD (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SORBS3 →	-0.229	-0.024	.001	.006	3	4
OV	LYSMD3_S134 →	-1.397	-0.075	.003	.003	3	4
COAD	MTM1_S18 →	-0.554	-0.042	<.001	<.001	3	4
LSCC	TRMT5 →	+0.339	+0.042	<.001	.001	3	4
CCRCC	LASP1 →	-0.190	-0.051	.003	.007	2	5
LSCC	NSUN6 →	+0.332	+0.063	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070989 vs SORBS3 — COAD

Explore this scatter interactively →