Oxidative demethylation

Across TCGA patient cohorts, RNA activity of the Oxidative demethylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AX, MORF4L1P3, and ENO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oxidative demethylation activity versus H2AX in HNSC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	H2AX →	+0.699	+0.155	<.001	.005	3	4
OV	MORF4L1P3 →	-1.063	-0.216	.006	.001	3	4
BRCA	ENO2 →	+0.789	+0.515	.002	.003	3	4
UCEC	PFKFB4 →	+0.717	+0.435	.008	.007	3	4
LUAD	BCKDK →	+0.412	+0.639	.004	<.001	3	3
LUAD	MANBA →	+0.393	+0.558	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070989 vs H2AX — HNSC

Explore this scatter interactively →