Oxidative demethylation

Across TCGA cell cohorts, RNA activity of the Oxidative demethylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIAS4, APBA3, and TAF6L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIAS4 grouped by Oxidative demethylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PIAS4 →	-0.762	-0.967	.001	<.001	3	5
SOFT_TISSUE	APBA3 →	-0.733	-1.332	.001	.009	3	4
LUNG_SCLC	TAF6L →	-0.884	-1.227	.001	.001	3	4
SOFT_TISSUE	IRS1 →	-1.800	-1.073	.009	.003	3	4
CNS	NINL →	-1.644	-1.010	.003	<.001	3	4
CNS	NONO →	-0.486	-1.044	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIAS4 by Oxidative demethylation activity — BREAST

Explore this box plot interactively →