Demethylation

Across TCGA patient cohorts, RNA activity of the Demethylation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPA2, SF3B6, and CD93, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Demethylation activity versus RPA2 in PDAC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPA2 →	+0.313	+0.039	<.001	<.001	3	5
LSCC	SF3B6 →	+0.218	+0.030	.001	.003	2	6
LSCC	CD93 →	-0.296	-0.027	.001	.003	3	5
PDAC	HDAC3 →	+0.239	+0.033	<.001	<.001	3	5
LSCC	HNRNPR →	+0.250	+0.031	<.001	.002	2	6
LSCC	NOS3 →	-0.216	-0.027	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070988 vs RPA2 — PDAC

Explore this scatter interactively →