Protein K11-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K11-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHEK2, KPNB1, and PTRH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked ubiquitination activity versus CHEK2 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHEK2 →	+0.646	+0.623	<.001	.007	3	4
LUAD	KPNB1 →	+0.243	+0.404	.001	.002	3	4
LSCC	PTRH2 →	+0.408	+0.618	.002	.003	3	4
LSCC	SPC25 →	+0.755	+0.787	.001	.002	3	3
BRCA	FUCA2 →	+0.302	+0.471	.001	.004	3	3
BRCA	UTP6 →	+0.276	+0.530	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070979 vs CHEK2 — BRCA

Explore this scatter interactively →