Protein K11-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K11-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATIC, CAPN5, and TFPI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATIC grouped by Protein K11-linked ubiquitination-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ATIC →	+0.748	+0.302	.002	<.001	3	5
BREAST	CAPN5 →	+1.787	+0.208	<.001	.001	3	4
LIVER	TFPI2 →	+4.313	+0.252	.004	.005	2	5
LUNG_SCLC	SEPTIN5 →	-1.816	-0.252	<.001	.001	3	4
LUNG_SCLC	KIFC3 →	+3.516	+0.298	<.001	.004	3	4
OESOPHAGUS	ADHFE1 →	+1.984	+0.296	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATIC by Protein K11-linked ubiquitination activity — CNS

Explore this box plot interactively →