Protein K11-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K11-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBRSL1, LSM6, and ORAI3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked ubiquitination activity versus FBRSL1 in BLOOD_Lymphoma (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FBRSL1 →	+1.095	+0.587	.002	.006	3	6
OVARY	LSM6 →	+1.176	+0.678	<.001	<.001	3	6
URINARY_TRACT	ORAI3 →	-1.642	-0.698	.004	.009	3	5
LIVER	LAMA3 →	-2.784	-1.049	.001	.002	3	5
LARGE_INTESTINE	UBE2D3 →	+0.701	+0.773	.002	.003	3	5
OVARY	PARK7 →	+0.544	+0.632	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070979 vs FBRSL1 — BLOOD_Lymphoma

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