Protein localization to endoplasmic reticulum exit site

Across TCGA patient cohorts, RNA activity of the Protein localization to endoplasmic reticulum exit site pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP1, CORO1A, and ARPC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to endoplasmic reticulum exit site activity versus LCP1 in LSCC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LCP1 →	+0.489	+0.084	<.001	<.001	3	6
LSCC	CORO1A →	+0.540	+0.098	<.001	<.001	3	6
CCRCC	ARPC2 →	+0.226	+0.063	<.001	<.001	3	5
GBM	SAMHD1 →	+0.361	+0.070	<.001	<.001	3	5
LSCC	SEPTIN6 →	+0.351	+0.084	<.001	<.001	3	5
LSCC	ATG7 →	+0.251	+0.108	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070973 vs LCP1 — LSCC

Explore this scatter interactively →