Protein localization to endoplasmic reticulum exit site

Across TCGA patient cohorts, RNA activity of the Protein localization to endoplasmic reticulum exit site pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF333, AKT3, and BRSK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to endoplasmic reticulum exit site activity versus ZNF333 in LSCC (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF333 →	-0.342	-0.633	.002	.005	3	6
BRCA	AKT3 →	-0.709	-0.652	.001	.002	3	5
GBM	BRSK1 →	-0.690	-0.702	<.001	<.001	3	5
UCEC	SYT11 →	-0.774	-0.717	<.001	<.001	3	5
GBM	FXYD6 →	-0.924	-0.578	<.001	<.001	3	5
GBM	APBB1 →	-0.800	-1.003	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070973 vs ZNF333 — LSCC

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