Protein localization to endoplasmic reticulum exit site

Across TCGA cell cohorts, RNA activity of the Protein localization to endoplasmic reticulum exit site pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARAP1, SLC35A2, and DGAT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARAP1 grouped by Protein localization to endoplasmic reticulum exit site-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ARAP1 →	+0.866	+0.465	.003	.008	3	4
OESOPHAGUS	SLC35A2 →	+0.835	+0.711	<.001	.008	3	3
LUNG_SCLC	DGAT1 →	+0.933	+1.183	.005	.007	2	4
BREAST	H2AW →	-1.325	-0.504	.003	<.001	3	3
BREAST	H4C14 →	-1.602	-0.521	<.001	<.001	3	3
BREAST	H4C5 →	-0.772	-0.595	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARAP1 by Protein localization to endoplasmic reticulum exit site activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →