Protein localization to endoplasmic reticulum exit site

Across TCGA cell cohorts, RNA activity of the Protein localization to endoplasmic reticulum exit site pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BICDL1, FOXA1, and CREB3L4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to endoplasmic reticulum exit site activity versus BICDL1 in BREAST (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BICDL1 →	+2.099	+0.328	.002	<.001	3	7
BREAST	FOXA1 →	+3.761	+0.385	<.001	<.001	3	6
BREAST	CREB3L4 →	+2.346	+0.360	<.001	<.001	3	6
BREAST	XBP1 →	+2.262	+0.357	<.001	<.001	3	6
LUNG_SCLC	MAP7 →	+2.261	+0.358	<.001	<.001	2	7
BREAST	CRACR2B →	+3.153	+0.381	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070973 vs BICDL1 — BREAST

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