Protein localization to endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Protein localization to endoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRPS18A, TNS2_S102, and TNS2_S120, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to endoplasmic reticulum activity versus MRPS18A in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRPS18A →	-0.328	-0.046	<.001	<.001	3	7
LSCC	TNS2_S102 →	+0.692	+0.047	<.001	<.001	3	6
OV	TNS2_S120 →	+0.613	+0.039	<.001	.001	3	6
OV	DOCK11 →	+0.419	+0.028	<.001	.003	3	6
OV	LRPPRC →	-0.316	-0.035	.008	.003	3	6
GBM	FRZB →	+0.550	+0.041	.005	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070972 vs MRPS18A — LSCC

Explore this scatter interactively →