Protein localization to endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Protein localization to endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC29A2, IKZF2, and APOL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC29A2 grouped by Protein localization to endoplasmic reticulum-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC29A2 →	+1.165	+0.724	.005	.004	3	4
BONE	IKZF2 →	+2.507	+0.302	.004	.003	3	4
SKIN	APOL3 →	-1.311	-0.632	.002	.008	3	4
LUNG_NSCLC_LUSC	PLA2G6 →	+1.655	+1.931	.003	<.001	3	4
PANCREAS	PFDN4 →	-0.900	-0.975	.006	.004	3	3
PANCREAS	CYP51A1 →	+1.192	+1.057	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC29A2 by Protein localization to endoplasmic reticulum activity — OVARY

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