Protein localization to endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Protein localization to endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOQ, PRICKLE1, and IER3IP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to endoplasmic reticulum activity versus RHOQ in STOMACH (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RHOQ →	-1.132	-0.179	.001	<.001	3	5
STOMACH	PRICKLE1 →	-2.282	-0.192	.008	.009	3	5
LUNG_NSCLC_LUSC	IER3IP1 →	+1.315	+0.186	.001	<.001	3	5
BREAST	RNF103 →	+0.798	+0.172	<.001	.006	3	5
BREAST	ATP2C2 →	+2.286	+0.196	<.001	<.001	3	5
LARGE_INTESTINE	TCF7L1 →	-0.705	-0.123	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070972 vs RHOQ — STOMACH

Explore this scatter interactively →