Protein K48-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K48-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, TUBB6, and HAPLN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K48-linked ubiquitination activity versus UCHL1 in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UCHL1 →	+0.942	+0.040	.003	<.001	3	7
BRCA	TUBB6 →	+0.419	+0.029	<.001	.001	3	5
BRCA	HAPLN3 →	+0.622	+0.039	<.001	<.001	3	5
COAD	MMP14 →	+0.366	+0.018	<.001	.001	3	5
COAD	MXRA5 →	+0.523	+0.016	.002	.005	3	5
GBM	PTBP2 →	+0.604	+0.041	.008	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070936 vs UCHL1 — LSCC

Explore this scatter interactively →