Protein K48-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K48-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNB1, TNXB, and GREB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K48-linked ubiquitination activity versus CCNB1 in PDAC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCNB1 →	+0.606	+0.477	.001	.004	2	5
HNSC	TNXB →	-0.934	-0.602	.002	<.001	3	4
HNSC	GREB1 →	-0.367	-0.419	.005	.009	3	4
BRCA	JAM3 →	-0.500	-0.463	.002	.001	3	4
COAD	MSRB3 →	-0.924	-0.615	<.001	.003	3	4
COAD	MIR100HG →	-0.491	-0.720	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070936 vs CCNB1 — PDAC

Explore this scatter interactively →