Protein K48-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K48-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLM2, EMP1, and CD109, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOLM2 grouped by Protein K48-linked ubiquitination-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GOLM2 →	+0.879	+0.157	.002	.003	3	5
BONE	EMP1 →	+5.149	+0.516	.002	.004	3	5
BONE	CD109 →	+2.250	+0.331	<.001	.005	3	5
STOMACH	JAGN1 →	-0.467	-0.188	.001	.004	3	5
LIVER	NIN →	+1.470	+0.384	.004	.009	3	4
LIVER	CTSL →	+1.663	+0.390	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOLM2 by Protein K48-linked ubiquitination activity — SOFT_TISSUE

Explore this box plot interactively →