Protein K48-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K48-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5PF, PSMG1, and HNRNPA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K48-linked ubiquitination activity versus ATP5PF in BREAST (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATP5PF →	+0.596	+0.600	.002	.007	3	7
SKIN	PSMG1 →	+0.917	+0.685	<.001	.004	3	5
BONE	HNRNPA1 →	+0.894	+1.874	<.001	<.001	3	5
BONE	MAST1 →	+2.253	+1.882	<.001	<.001	3	5
BONE	CARD19 →	-1.440	-1.624	.004	.002	3	5
KIDNEY	TXNL4A →	+0.812	+1.114	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070936 vs ATP5PF — BREAST

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