3'-UTR-mediated mRNA stabilization

Across TCGA patient cohorts, RNA activity of the 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPDC1_S547, TBC1D10B_S633, and PGAM1_S31, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-UTR-mediated mRNA stabilization activity versus PTPDC1_S547 in HNSC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PTPDC1_S547 →	+0.583	+0.093	.002	<.001	3	5
BRCA	TBC1D10B_S633 →	+0.380	+0.042	.001	<.001	2	5
UCEC	PGAM1_S31 →	-0.559	-0.054	.001	.004	3	4
HNSC	SQOR →	-0.380	-0.061	.002	.005	3	4
LUAD	METTL16 →	+0.190	+0.045	<.001	<.001	3	4
PDAC	MAP1B_S1016 →	+0.431	+0.029	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070935 vs PTPDC1_S547 — HNSC

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