3'-UTR-mediated mRNA stabilization

Across TCGA cell cohorts, RNA activity of the 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRA10AC1, FSD1L, and STK19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRA10AC1 grouped by 3'-UTR-mediated mRNA stabilization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FRA10AC1 →	+0.912	+0.369	<.001	<.001	3	6
LUNG_NSCLC_LUSC	FSD1L →	+0.896	+0.367	.001	.001	3	4
BLOOD_Leukemia	STK19 →	+0.630	+0.305	<.001	<.001	3	4
BLOOD_Myeloma	PSMD10 →	+0.908	+0.360	.002	<.001	3	3
BLOOD_Myeloma	CCDC93 →	+0.708	+0.228	.006	.004	3	3
BLOOD_Myeloma	ATP1B1 →	+1.103	+0.231	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRA10AC1 by 3'-UTR-mediated mRNA stabilization activity — BLOOD_Leukemia

Explore this box plot interactively →