3'-UTR-mediated mRNA stabilization

Across TCGA cell cohorts, RNA activity of the 3'-UTR-mediated mRNA stabilization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF25, UNC93B1, and ARRDC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 3'-UTR-mediated mRNA stabilization activity versus ARHGEF25 in BLOOD_Myeloma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ARHGEF25 →	+2.477	+0.187	.009	.007	2	7
STOMACH	UNC93B1 →	-2.074	-0.232	.002	.007	3	6
BREAST	ARRDC1 →	-1.614	-0.219	<.001	<.001	3	6
OVARY	RBM47 →	-2.560	-0.169	<.001	<.001	3	5
PANCREAS	SMIM10L1 →	+0.996	+0.194	<.001	.001	3	5
OVARY	ATP6AP1 →	-0.637	-0.112	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070935 vs ARHGEF25 — BLOOD_Myeloma

Explore this scatter interactively →