RISC complex assembly

Across TCGA cell cohorts, RNA activity of the RISC complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBXIP1, HINT1, and HPCAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RISC complex assembly activity versus PBXIP1 in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PBXIP1 →	+1.615	+0.228	<.001	<.001	3	6
BLOOD_Leukemia	HINT1 →	-0.455	-0.113	<.001	.004	3	5
OVARY	HPCAL1 →	-1.743	-0.214	.001	.001	3	4
BREAST	PARK7 →	-0.542	-0.196	.001	<.001	3	4
BREAST	KLF16 →	-0.623	-0.210	.005	.002	3	4
UPPER_AERODIGESTIVE_TRACT	DOHH →	-0.877	-0.426	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070922 vs PBXIP1 — LUNG_SCLC

Explore this scatter interactively →