Regulation of regulatory ncRNA processing

Across TCGA patient cohorts, RNA activity of the Regulation of regulatory ncRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP6V1G2, DDAH2, and HYI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of regulatory ncRNA processing activity versus ATP6V1G2 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATP6V1G2 →	+0.686	+0.024	<.001	<.001	3	5
LSCC	DDAH2 →	+0.270	+0.038	.006	.004	3	5
BRCA	HYI →	+0.357	+0.029	.004	.002	3	5
PDAC	UQCRQ →	-0.294	-0.050	.005	.003	3	4
HNSC	VDAC2_T68 →	-0.707	-0.066	<.001	.009	3	4
BRCA	SERPINA1 →	+0.417	+0.025	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070920 vs ATP6V1G2 — BRCA

Explore this scatter interactively →