Regulation of regulatory ncRNA processing

Across TCGA patient cohorts, RNA activity of the Regulation of regulatory ncRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGAT3, NPFFR1, and DIPK1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of regulatory ncRNA processing activity versus MGAT3 in GBM (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MGAT3 →	-0.792	-0.180	<.001	<.001	3	4
LUAD	NPFFR1 →	-0.216	-0.127	.005	.002	3	3
LUAD	DIPK1A →	-0.461	-0.211	<.001	<.001	3	3
HNSC	NOMO2 →	+0.511	+0.475	.001	.002	3	3
LUAD	MGAT3-AS1 →	-0.471	-0.121	<.001	.003	3	3
LUAD	KRTCAP2P1 →	+0.271	+0.151	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070920 vs MGAT3 — GBM

Explore this scatter interactively →