UV-damage excision repair

Across TCGA patient cohorts, RNA activity of the UV-damage excision repair pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHOSPHO2, POLA1, and KIF27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UV-damage excision repair activity versus PHOSPHO2 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PHOSPHO2 →	+0.514	+0.223	.003	<.001	3	4
CCRCC	POLA1 →	+0.276	+0.176	<.001	<.001	3	4
CCRCC	KIF27 →	+0.256	+0.150	.005	.003	3	4
BRCA	MSI2 →	+0.640	+0.227	<.001	<.001	3	3
BRCA	MRAS →	-0.743	-0.272	.001	<.001	3	3
PDAC	MFAP3L →	-0.392	-0.156	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070914 vs PHOSPHO2 — BRCA

Explore this scatter interactively →