Transcription preinitiation complex assembly

Across TCGA patient cohorts, RNA activity of the Transcription preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTL, TROAP, and CENPO, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription preinitiation complex assembly activity versus DTL in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DTL →	+1.080	+1.305	<.001	<.001	3	7
UCEC	TROAP →	+1.242	+1.118	<.001	<.001	3	7
UCEC	CENPO →	+0.753	+1.141	<.001	<.001	3	7
UCEC	DNA2 →	+0.808	+1.247	<.001	<.001	3	7
UCEC	PIF1 →	+1.074	+1.064	<.001	.001	3	7
UCEC	BIRC5 →	+0.836	+0.942	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070897 vs DTL — HNSC

Explore this scatter interactively →