Transcription preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the Transcription preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35E1, NDUFA13, and GPR180, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC35E1 grouped by Transcription preinitiation complex assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC35E1 →	-0.685	-0.163	.002	.005	3	6
LIVER	NDUFA13 →	-1.009	-0.312	.005	.006	3	6
BLOOD_Myeloma	GPR180 →	-0.812	-0.166	.001	.001	3	6
PANCREAS	UIMC1 →	-0.681	-0.225	.005	<.001	3	5
LUNG_SCLC	CDCP1 →	+3.049	+0.308	<.001	.005	3	5
BLOOD_Leukemia	NAA38 →	-1.522	-0.215	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC35E1 by Transcription preinitiation complex assembly activity — BREAST

Explore this box plot interactively →