Transcription preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the Transcription preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTSS1, SELENOW, and ZNF146, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription preinitiation complex assembly activity versus MTSS1 in PANCREAS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MTSS1 →	+2.102	+0.468	.001	<.001	3	5
BLOOD_Lymphoma	SELENOW →	-1.868	-0.339	.004	<.001	3	5
LUNG_SCLC	ZNF146 →	+0.918	+0.405	.009	.005	3	5
BLOOD_Lymphoma	GOLGA1 →	-0.700	-0.397	.001	.001	3	5
BONE	RFX7 →	+0.838	+0.351	.005	.004	3	5
BLOOD_Lymphoma	RETSAT →	-0.717	-0.315	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070897 vs MTSS1 — PANCREAS

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