Positive regulation of glycogen metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of glycogen metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JPT1, CTSF, and PURA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glycogen metabolic process activity versus JPT1 in COAD (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JPT1 →	-0.394	-0.040	<.001	.001	3	5
HNSC	CTSF →	+0.689	+0.083	<.001	<.001	3	5
BRCA	PURA →	+0.364	+0.043	.003	.004	3	5
UCEC	ARHGEF40 →	+0.215	+0.048	<.001	.002	3	5
UCEC	SARM1 →	+0.545	+0.059	<.001	.003	3	5
OV	SEPTIN4 →	+0.423	+0.045	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070875 vs JPT1 — COAD

Explore this scatter interactively →