Positive regulation of glycogen metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of glycogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM3, TMEM86A, and UFSP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM3 grouped by Positive regulation of glycogen metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RBM3 →	-1.196	-1.497	.002	<.001	3	5
BREAST	TMEM86A →	+1.271	+0.703	.009	.006	3	4
BLOOD_Leukemia	UFSP2 →	-0.544	-0.648	.002	.009	3	4
LUNG_NSCLC_LUAD	UGDH →	-1.119	-0.537	.004	.004	3	3
LUNG_NSCLC_LUAD	CD24 →	+2.041	+0.699	.003	.008	3	3
STOMACH	SYT7 →	+2.083	+0.629	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM3 by Positive regulation of glycogen metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →